Adipocyte size

Continuous intake of Trehalose induces white adipose tissue Browning and Enhances energy metabolism

Chikako Arai, Norie Arai, Shigeyuki Arai, Chiyo Yoshizane, Satomi Miyata, Akiko Mizote, Aki Suyama, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi & Shimpei Ushio

Background Trehalose is well known as a functional disaccharide with anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Recently, a new type of adipocyte beige cells, involved in so-called white adipocyte tissue (WAT) browning, has received much attention as a target for adaptive thermogenesis. To clarify the relationship between adipocyte hypertrophy suppression and beige cells involved in thermogenesis, …

Nutr. Metab. 2020;16:45.
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Trehalose itself plays a critical role on lipid metabolism: Trehalose increases jejunum cytoplasmic lipid droplets which negatively correlated with mesenteric adipocyte size in both HFD-fed trehalase KO and WT mice

Chikako Arai, Aki Suyama, Shigeyuki Arai, Norie Arai, Chiyo Yoshizane, Satomi Koya-Miyata, Akiko Mizote, Shin Endo, Toshio Ariyasu, Hitoshi Mitsuzumi & Shimpei Ushio

Background Trehalose is a functional disaccharide that has anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans. Trehalase hydrolyzes trehalose in the small intestine into two glucose molecules. In this study, we investigated whether trehalose can suppress adipocyte hypertrophy in mice in the presence or absence of trehalase. Methods Trehalase knockout (KO) mice and wild-type (WT) mice were fed …

Nutr. Metab. 2020;17:22.
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