Trehalose attenuates development of nonalcoholic steatohepatitis associated with type 2 diabetes in TSOD mouse
Kazutoshi Murotomi, Shigeyuki Arai, Aki Suyama, Akira Harashima, Yoshihiro Nakajima
Trehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We …J. Funct. Foods. 2019;56:303-311.