The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice
Aneta Stachowicz, Anna Wiśniewska, Katarzyna Kuś, Anna Kiepura, Anna Gębska, Mariusz Gajda, Magdalena Białas, Justyna Totoń-Żurańska, Kamila Stachyra, Maciej Suski, Jacek Jawień, Ryszard Korbut and Rafał Olszanecki
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Western countries. Recently, it has been shown that autophagy dysfunction plays an important role in the pathogenesis of both atherosclerosis and NAFLD; thus, activators of autophagy might be useful for novel therapeutic interventions. Trehalose—a naturally occuring disaccharide present in plants, bacteria, fungi, insects, and certain types of shrimps—is a known inducer of autophagy. However, …Int. J. Mol. Sci. 2019;20:1552.