Chikako Shimokawa, Tamotsu Kato, Tadashi Takeuchi, Noriyasu Ohshima, Takao Furuki, Yoshiaki Ohtsu, Kazutomo Suzue, Takashi Imai, Seiji Obi, Alex Olia, Takashi Izumi, Minoru Sakurai, Hirokazu Arakawa, Hiroshi Ohno & Hajime Hisaeda
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing pancreatic β-cells are destroyed. Intestinal helminths can cause asymptomatic chronic and immunosuppressive infections and suppress disease in rodent models of T1D. However, the underlying regulatory mechanisms for this protection are unclear. Here, we report that CD8+ regulatory T (Treg) cells prevent the onset of streptozotocin -induced diabetes by a rodent intestinal nematode. Trehalose derived from nematodes affects the …Nat. Commun. 2020;11:1922.