Portbury, Stuart D., Hare, Dominic J., Sgambelloni, Charlotte, Perronnes, Kali, Portbury, Ashley J., Finkelstein, David I. & Adlard, Paul A.
This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer’s disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition metals, iron, copper, and zinc, are understood to be intricately involved in the cellular cascades leading to the defining pathologies of the …J. Alzheimers Dis. 2017;60:549–560.