Tg2576

Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer’s Disease

Portbury, Stuart D., Hare, Dominic J., Sgambelloni, Charlotte, Perronnes, Kali, Portbury, Ashley J., Finkelstein, David I. & Adlard, Paul A.

This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide trehalose in the Tg2576 transgenic mouse model of Alzheimer’s disease (AD) via an oral gavage of a 2% trehalose solution for 31 days. Furthermore, as AD is a neurodegenerative condition in which the transition metals, iron, copper, and zinc, are understood to be intricately involved in the cellular cascades leading to the defining pathologies of the …

J. Alzheimers Dis. 2017;60:549–560.
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